(±) -Carnitine-d9 (chloride)

(±) -Carnitine-d9 (chloride) is the deuterium labeled (±) -Carnitine chloride. (±) -Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.

Product Specifications

CAS Number

[1219386-75-0]

Product Name Alternative

DL-Carnitine-d9 (chloride)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CC(O)CC(O)=O.[Cl-]

Molecular Formula

C7H7D9ClNO3

Molecular Weight

206.72

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Oyanagi E, et al. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acidstress. Biochem Biophys Res Commun. 2011 Aug 19;412 (1) :61-7.|[3]Li J, et al. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can J Physiol Pharmacol. 2016 May;94 (5) :517-25.|[4]Jang J, et al. l-Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats. Appl Physiol Nutr Metab. 2016 Dec;41 (12) :1240-1247.|[5]Zambrano S, et al. L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. Am J Hypertens. 2014 Mar;27 (3) :460-70.