Medetomidine-13C, d3 (hydrochloride)

Medetomidine-13C, d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) [1]. Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM) . Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels[2][3][4][5].

Product Specifications

CAS Number

[1216630-06-6]

Product Name Alternative

MPV785-13C, d3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

99.48

Smiles

CC1=C(C)C(C(C2=CN=CN2)[13C]([2H])([2H])[2H])=CC=C1.Cl

Molecular Formula

C12 13CH14D3ClN2

Molecular Weight

240.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kallio A, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh) . 1988 Sep;119 (1) :11-5. |[3]R Virtanen, et al. Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. |[4]O. B. Ansah, et al. Comparing oral and intramuscular administration of medetomidine in cats. |[5]Kuo WC, et al. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul;65 (7) :931-7. |[6]Yakoub LK, et al. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19;93 (1) :1-8. |[7]Jager LP, et al. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3;346 (1) :71-6. |[8]Ulrika Lind, et al. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. |[9]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.