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Ampreloxetine (hydrochloride)

Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT) . Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma[1].

Product Specifications

CAS Number

1227056-87-2

Product Name Alternative

TD-9855 (hydrochloride)

UNSPSC

12352005

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ampreloxetine-hydrochloride.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(C(F)=CC(F)=C1)OCC2=C(C3CCNCC3)C=CC=C2.Cl

Molecular Formula

C18H19ClF3NO

Molecular Weight

357.80

References & Citations

[1]Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18 (2) :pyu027.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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