Ac-Trp-Glu-His-Asp-Aldehyde

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

Product Specifications

CAS Number

[189275-71-6]

UNSPSC

12352209

Target

Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-trp-glu-his-asp-aldehyde.html

Solubility

10 mM in DMSO

Smiles

OC(C[C@@H](C=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O

Molecular Formula

C28H33N7O9

Molecular Weight

611.60

References & Citations

[1]Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17 (9) :999-1007. |[2]Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE) . Chem Biol. 1997 Feb;4 (2) :149-55.