Me-SJ46411-PEG1-Piperazine-Boc
Me-SJ46411-PEG1-Piperazine-Boc is a conjugate of E3 ubiquitin ligase and PROTAC linker, which can be used for the synthesis of PROTAC molecules. For example, Me-SJ46411-PEG1-Piperazine-Boc combined with target protein ligand (+) -JQ-1 can be used to synthesize the selective BRD3 PROTAC degrader SJ46420 (HY-168635).[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plus-jq-1-piperazine-c2-oh.html
Smiles
O=C(CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(OC(C)(C)C)=O)CC4)C3=C2)=N1)=O)OC
Molecular Formula
C29H36N4O6S
Molecular Weight
568.68
References & Citations
[1]Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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