Apelin-17 (human, bovine) (TFA)
Apelin-17 (human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17 (human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02) . Apelin-17 (human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Apelin Receptor (APJ) ; HIV
Type
Peptides
Related Pathways
Anti-infection; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/apelin-17-human-bovine-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCCN)C(NCC(N4[C@@H](CCC4)C(N[C@@H](CCSC)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Molecular Formula
C98H157F3N34O22S
Molecular Weight
2252.57
References & Citations
[1]Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251 (2) :471-476.|[2]Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84 (5) :1162-1172.|[3]Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV) . FEBS Lett. 2000;473 (1) :15-18.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HIV-1; HIV-2
Frequently Asked Questions
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