Anti-Glycogen Phosphorylase, brain, Antibody

Rabbit Polyclonal Antibody specific to Glycogen Phosphorylase, brain

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 2.4.1.1

Gene Name

PYGB

NCBI Gene ID

UniProt

P11216

Accession Number

NP_002853.2

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH.

Target Antigen

Glycogen phosphorylase, brain form

Clonality

Polyclonal

Type

Antibody

Applications

IHC, IHC-P

Field of Research

Enzymes

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {PubMed:27402852, PubMed:3346228}.

Additionnal Information

<br><br>Immunohistochemistry: Use at 10ug/ml.

Storage Conditions

This antibody is stable at 4°C (short- term) and -70°C (long-term).

Specificity

This antibody recognizes an internal domain of human brain GP.

Formulation

PBS containing 0.1% sodium azide

Target Background

Glycogen phosphorylase (GP) removes and converts one glucose molecule from glycogen to glucose-1-phosphate. Mammalian GPs are found in at least three isozymic forms that are distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed. The brain isozyme of GP is associated primarily with providing an emergency glucose supply during periods of anoxia or hypoglycemia. A549 non-small cell lung carcinoma cells express solely the brain isozyme of GP and have been used to investigate inhibitors of GP that retard cell growth.