JMV-1645

JMV-1645 is a potent and selective B1 bradykinin receptor antagonist with a Ki value of 0.023 nM on the human cloned B1 receptor. JMV-1645 can be utilized in trauma and infection research[1].

Product Specifications

CAS Number

[284037-77-0]

UNSPSC

12352209

Target

Bradykinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jmv-1645.html

Smiles

O=C(N(C1=CC=CC=C1SC2)CC(O)=O)[C@@H]2NC([C@H](CO)NC([C@H](C3CC4=CC=CC=C4C3)NC(CNC([C@H]5N(C[C@@H](C5)O)C([C@H]6N(CCC6)C([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C49H69N13O12S

Molecular Weight

1064.22

References & Citations

[1]Bedos P, et al. A rational approach to the design and synthesis of a new bradykinin B (1) receptor antagonist. J Med Chem. 2000 Jun 15;43 (12) :2387-94.