MC0704
MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC) [1].
Product Specifications
CAS Number
3034176-57-0
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc0704.html
Purity
98.34
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(C(NCCC2=CNC3=C2C=CC=C3)=O)=CC4=C1NC5=CC=CC=C54)C6=CC=C(C=C6)Br
Molecular Formula
C29H21BrN4O2
Molecular Weight
537.41
References & Citations
[1]Byun WS, et al. Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66 (4) :3106-3133.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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