Tezacitabine

Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment[1][2].

Product Specifications

CAS Number

[130306-02-4]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tezacitabine.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

F/C=C1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]/1O

Molecular Formula

C10H12FN3O4

Molecular Weight

257.22

References & Citations

[1]Janusz S Skierski, et al. Tezacitabine Blocks Tumor Cells in G1 and S Phases of the Cell Cycle and Induces Apoptotic Cell Death. Acta Pol Pharm. May-Jun 2005;62 (3) :195-205.|[2]Pietro Taverna, et al. Tezacitabine Enhances the DNA-directed Effects of Fluoropyrimidines in Human Colon Cancer Cells and Tumor Xenografts. Biochem Pharmacol. 2007 Jan 1;73 (1) :44-55.