WJ460
WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity[1][2].
Product Specifications
CAS Number
[1415251-36-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wj460.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NCCCCC1=CC=CC=C1)C2=CC=CC(C(N3C4=CC=CC=C4OC)SCC3=O)=C2
Molecular Formula
C27H28N2O3S
Molecular Weight
460.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9 (1) :3726.|[2]Rademaker G, et al. Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biol. 2022 Jul;53:102324.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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