USP7-IN-16
USP7-IN-16 (Compound 61) is a selective USP7 inhibitor with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. USP7-IN-16 exhibits antitumor activity in mice and is a promising candidate for research in the field of oncology[1].
Product Specifications
CAS Number
2166587-77-3
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/usp7-in-16.html
Smiles
O=C1C2=C(N=CN1CC3(CCN(CC3)C([C@H]4[C@H](C5=CC=CC=C5)CN(CC4)C(C6=C(C)N=C(C7=CN=C(C)C=C7)S6)=O)=O)O)N(C8=CC(OC)=CC(OC)=C8)C=C2
Molecular Formula
C43H45N7O6S
Molecular Weight
787.93
References & Citations
[1]Venturi L, et al. Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors. ACS Med Chem Lett. 2024 Oct 23;15 (11) :1925-1932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
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