Macrophage-activating lipopeptide 2
Product Specifications
UNSPSC Description
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL)[1].
Target Antigen
NO Synthase; Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/macrophage-activating-lipopeptide-2.html
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCCCN)=O)=O)[C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC(CNC([C@@H](N)CSC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1
Molecular Weight
2135.56
References & Citations
[1]Troidl K, et al. The Lipopeptide MALP-2 Promotes Collateral Growth. Cells. 2020 Apr 16;9(4):997.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10586/Macrophage-activating-lipopeptide-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10586/
Clinical Information
Phase 1
CAS Number
250718-44-6
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