OTS447
OTS447 is a potent FLT3 inhibitor with an IC50 of 21 nM (WO2012016082A1, compound 335) [1].
Product Specifications
CAS Number
1356943-67-3
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ots447.html
Purity
99.83
Solubility
DMSO : 12.41 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
CC(C1=C(NC2CCC(N(CC)CC)CC2)C3=CC(C4=CC=C(O)C(Cl)=C4)=CC=C3N=C1)=O
Molecular Formula
C27H32ClN3O2
Molecular Weight
466.01
References & Citations
[1]Yo Matsuo, et al. Quinoline derivatives and melk inhibitors containing the same. WO2012016082A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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