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OTS447

OTS447 is a potent FLT3 inhibitor with an IC50 of 21 nM (WO2012016082A1, compound 335) [1].

Product Specifications

CAS Number

1356943-67-3

UNSPSC

12352005

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ots447.html

Purity

99.83

Solubility

DMSO : 12.41 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)

Smiles

CC(C1=C(NC2CCC(N(CC)CC)CC2)C3=CC(C4=CC=C(O)C(Cl)=C4)=CC=C3N=C1)=O

Molecular Formula

C27H32ClN3O2

Molecular Weight

466.01

References & Citations

[1]Yo Matsuo, et al. Quinoline derivatives and melk inhibitors containing the same. WO2012016082A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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