L 858051

L 858051 is an analog of Forskolin (HY-15371) that activates adenylate cyclase while also having modulatory effects on intracellular cAMP levels, particularly enhancing the CNG current in cardiac myocytes[1].

Product Specifications

CAS Number

[110452-75-0]

Product Name Alternative

7DMB-Forskolin (free base)

UNSPSC

12352005

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/l-858051.html

Smiles

O=C(CCCN1CCN(CC1)C)O[C@H]2[C@H]([C@]3(C(C)(CC[C@@H]([C@@]3([C@@]4([C@@]2(O[C@@](C=C)(CC4=O)C)C)O)C)O)C)[H])O

Molecular Formula

C29H48N2O7

Molecular Weight

536.70

References & Citations

[1]Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels