(E/Z) -Afatinib (Standard)
(E/Z) -Afatinib (Standard) is the analytical standard of (E/Z) -Afatinib. This product is intended for research and analytical applications. (E/Z) -Afatinib ((E/Z) -BIBW 2992) is the mixture of (E) -Afatinib and (Z) -Afatinib. Afatinib is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1].
Product Specifications
CAS Number
439081-18-2
Product Name Alternative
(E/Z) -BIBW 2992 (Standard)
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; c-Met/HGFR; EGFR; p38 MAPK; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; MAPK/ERK Pathway; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-z-afatinib-standard.html
Smiles
O=C(/C=C/CN(C)C)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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