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PROTAC METTL3 degrader 1

PROTAC METTL3 degrader 1 (Compound KH12) is a VHL-based PROTAC METTL3 degrader (DC50: 220 nM in MOLM-13 cells) . PROTAC METTL3 degrader 1 inhibits METTL3/14 complex with an IC50 value of 341 nM. PROTAC METTL3 degrader 1 has anti-proliferative activities against AML cells. Black: Linker (HY-ER002) ; Red: METTL3 ligand (HY-115717) ; Blue: VHL ligand (HY-120217) [1].

Product Specifications

UNSPSC

12352211

Target

METTL3; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-mettl3-degrader-1.html

Smiles

O=C1NC2(CCN(C3=NC=NC(NCCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=C3)CC2)CN(C7=C(F)C=C(CN8CCC(C)(C)CC8)C(F)=C7)C1

Molecular Formula

C56H77F2N11O5S

Molecular Weight

1054.34

References & Citations

[1]Hwang K, et al. Targeted degradation of METTL3 against acute myeloid leukemia and gastric cancer. Eur J Med Chem. 2024 Sep 6;279:116843.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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