PROTAC METTL3 degrader 1
PROTAC METTL3 degrader 1 (Compound KH12) is a VHL-based PROTAC METTL3 degrader (DC50: 220 nM in MOLM-13 cells) . PROTAC METTL3 degrader 1 inhibits METTL3/14 complex with an IC50 value of 341 nM. PROTAC METTL3 degrader 1 has anti-proliferative activities against AML cells. Black: Linker (HY-ER002) ; Red: METTL3 ligand (HY-115717) ; Blue: VHL ligand (HY-120217) [1].
Product Specifications
UNSPSC
12352211
Target
METTL3; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-mettl3-degrader-1.html
Smiles
Molecular Formula
C56H77F2N11O5S
Molecular Weight
1054.34
References & Citations
[1]Hwang K, et al. Targeted degradation of METTL3 against acute myeloid leukemia and gastric cancer. Eur J Med Chem. 2024 Sep 6;279:116843.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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