Avrainvillamide
Avrainvillamide ((+) -Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively[1][2][3].
Product Specifications
CAS Number
[269741-97-1]
Product Name Alternative
(+) -Avrainvillamide; CJ-17,665
UNSPSC
12352005
Target
Antibiotic
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/avrainvillamide.html
Purity
95.00
Solubility
DMSO : 2.23 mg/mL (ultrasonic; warming)
Smiles
O=C1[C@]23[C@@](C(C)(C4=[N+]([O-])C5=C6C(OC(C)(C=C6)C)=CC=C5C4=C3)C)([H])CC7(C(N2)=O)N1CCC7
Molecular Formula
C26H27N3O4
Molecular Weight
445.51
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10264/Avrainvillamide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10264/Avrainvillamide-SDS-MedChemExpress.pdf
Scientific Category
Natural Products
Clinical Information
No Development Reported
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