Cardionogen 1

Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that slows down Myc-induced liver tumorigenesis. Cardionogen 1 treatment of zebrafish embryos before gastrulation inhibits cardiomyocyte formation, whereas treatment during or after gastrulation induces cardiomyocyte formation. Cardionogen 1 has potential in research into cancer and cardiovascular disease[1][2].

Product Specifications

CAS Number

[577696-37-8]

Product Name Alternative

CDNG1/vuc230

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cardionogen-1.html

Purity

99.21

Solubility

10 mM in DMSO

Smiles

C12=NN=C(C3=CC=CO3)N1N=C(C4CCCCC4)S2

Molecular Formula

C13H14N4OS

Molecular Weight

274.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Yan C, et al. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017 Apr 5;7:45796.|[2]Plowright AT, et al. Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents. Angew Chem Int Ed Engl. 2014 Apr 14;53 (16) :4056-75.