AQX-435

AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth[1][2].

Product Specifications

CAS Number

[1619983-52-6]

UNSPSC

12352005

Target

Apoptosis; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aqx-435.html

Purity

99.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN=C1)N[C@@H]2C[C@@]3([H])C(C)(C)CCC[C@]3(C)[C@@H](C(C4=CC(O)=CC(O)=C4)=O)[C@@H]2C

Molecular Formula

C27H34N2O4

Molecular Weight

450.57

References & Citations

[1]Lyoyd F. MACKENZIE, et al. Ship1 modulators and methods related thereto.WO2014110036A1.|[2]Lemm EA, et al. Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells. Clin Cancer Res. 2020;26 (7) :1700-1711.