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PROTAC TYK2 degrader-1

PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with Dmax >60%. (Structure Note: PINK, TYK2 ligand 1 ; Blue, VHL ligand Thalidomide (HY-14658) ; Black, linker)

Product Specifications

CAS Number

2770470-20-5

UNSPSC

12352005

Target

JAK; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-tyk2-degrader-1.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CNC(C1=NN=C(C=C1NC2=CC=CC(C3=NN(C=N3)C)=C2OC)NC4=NC=C(C=C4)C(NCCCCCNC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O)=O)=O

Molecular Formula

C40H41N13O7

Molecular Weight

815.84

References & Citations

[1]Jing Liu, et al. Tyrosine kinase 2 (tyk2) degradation compounds and methods of use. US20240059671A1. 2024-02-22.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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