PROTAC TYK2 degrader-1
PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with Dmax >60%. (Structure Note: PINK, TYK2 ligand 1 (HY-158340) ; Blue, VHL ligand Thalidomide (HY-14658) ; Black, linker)
Product Specifications
CAS Number
[2770470-20-5]
UNSPSC
12352005
Target
JAK; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-tyk2-degrader-1.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC(C1=NN=C(C=C1NC2=CC=CC(C3=NN(C=N3)C)=C2OC)NC4=NC=C(C=C4)C(NCCCCCNC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O)=O)=O
Molecular Formula
C40H41N13O7
Molecular Weight
815.84
References & Citations
[1]Jing Liu, et al. Tyrosine kinase 2 (tyk2) degradation compounds and methods of use. US20240059671A1. 2024-02-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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