Desmethyl Sibutramine

Desmethyl Sibutramine, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine can be used in the research of obesity and appetite suppressant[1][2][3][4].

Product Specifications

CAS Number

[168835-59-4]

Product Name Alternative

N-Desmethylsibutramine

UNSPSC

12352005

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desmethyl-sibutramine.html

Purity

99.45

Solubility

10 mM in DMSO

Smiles

CC(C)CC(C1(C2=CC=C(Cl)C=C2)CCC1)NC

Molecular Formula

C16H24ClN

Molecular Weight

265.82

References & Citations

[1]Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11) C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35 (3) :741-51. |[2]Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28 (2) :129-34.|[3]Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25 (7) :822-30.|[4]Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2 (4) :249-257.