EGFR/DHFR-IN-1
EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR with IC50s of 0.151 and 0.541 µM, respectively. EGFR/DHFR-IN-1 arrests the cell cycle at both G0-G1 and S phases[1].
Product Specifications
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-dhfr-in-1.html
Smiles
O=C(N1CCN(CC1)CC(SC2=NC3=C(C(C)=C(S3)C(C)=O)C(N2C4=CC=CC=C4)=O)=O)OCC
Molecular Formula
C24H26N4O5S2
Molecular Weight
514.62
References & Citations
[1]Fouad M M, et al. Synthesis and in vitro antitumor evaluation of new thieno [2, 3-d] pyrimidine derivatives as EGFR and DHFR inhibitors[J]. Bioorganic Chemistry, 2024, 148: 107401.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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