Ascorbyl palmitate

Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172) . Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs) . Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome[1][2][3][4].

Product Specifications

CAS Number

[137-66-6]

Product Name Alternative

L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Calcium Channel; Caspase; Endogenous Metabolite; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; Sodium Channel

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ascorbyl-palmitate.html

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

OC([C@H](O1)[C@H](COC(CCCCCCCCCCCCCCC)=O)O)=C(O)C1=O

Molecular Formula

C22H38O7

Molecular Weight

414.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Sohrabi Y, et al. Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive[J]. Adv Pharm Bull. 2018 Jun;8 (2) :341-346.|[2]Ivanov V, et al. Inhibition of collagen synthesis by select calcium and sodium channel blockers can be mitigated by ascorbic acid and ascorbyl palmitate. Am J Cardiovasc Dis. 2016 May 18;6 (2) :26-35.|[3]Zhang L, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome[J]. Int Immunopharmacol. 2024 Apr 20;131:111915. |[4]Jonker D, et al. Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse[J]. Toxicology. 1988 Nov 30;52 (3) :287-95.