Methionylserine

Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension[1][2].

Product Specifications

CAS Number

[14517-43-2]

Product Name Alternative

H-MET-SER-OH

UNSPSC

12352209

Hazard Statement

H302-H312-H332

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/methionylserine.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CCSC)N[C@H](C(O)=O)CO

Molecular Formula

C8H16N2O4S

Molecular Weight

236.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Diana Højmark Omkvist, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77 (2) :327-31. |[2]Pan Wuguang, et al. Application of sulfur dipeptide for preparing antihypertensive drug or health care product. Patent WO2019006954.