Grp75 Recombinant Mouse Monoclonal Antibody [6-A9-R]
The HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. HSC 70, GRP 75 and GRP 78 are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
GRP-75, MOT, PBP74, HSPA9, GRP75, HSPA9B, mt-HSP70
Swiss Prot
P38646 Human, P38647 Mouse, P48721 Rat
Cellular Locus
Mitochondrion. Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within human Grp75 aa 101-150.
Isotype
IgG1
Clone
6-A9-R
Conjugation
Non-conjugated
Type
Recombinant Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 74 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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