PROTAC SMARCA2/4-degrader-29

PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1].

Product Specifications

CAS Number

[2568273-82-3]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-29.html

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C([C@@H]4CC[C@H](N5CCC(C6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=N6)CC5)CC4)C=C3N1C

Molecular Formula

C44H51N11O4

Molecular Weight

797.95

References & Citations

[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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