PROTAC SMARCA2/4-degrader-29
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1].
Product Specifications
CAS Number
[2568273-82-3]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-29.html
Smiles
O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C([C@@H]4CC[C@H](N5CCC(C6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=N6)CC5)CC4)C=C3N1C
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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