ABT-072 (potassium trihydrate)
Product Specifications
UNSPSC Description
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)[1][2][3].
Target Antigen
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/abt-072-potassium-trihydrate.html
Purity
99.59
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CS(=O)([N-]C1=CC=C(/C=C/C2=CC(N(C(N3)=O)C=CC3=O)=CC(C(C)(C)C)=C2OC)C=C1)=O.[H]O[H].[H]O[H].[H]O[H].[K+]
Molecular Weight
561.69
References & Citations
[1]Lawitz E, et al. A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1. J Hepatol. 2013;59(1):18-23.|[2]Shi Y, et al. Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method. J Pharm Sci. 2016;105(9):2886-2895.|[3]Randolph JT, et al. Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability. J Med Chem. 2018;61(3):1153-1163.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101634A/ABT-072-potassium-trihydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101634A/ABT-072-potassium-trihydrate-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1132940-31-8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal HDAC3 Antibody (PCRP-HDAC3-3C9) [HRP]](https://cdn.genprice.uk/genprice/genprice2.png)
MBS6282819-01 0.2 mL
CD163L1, CT (CD163L1, CD163B, M160, Scavenger receptor cysteine-rich type 1 protein M160, CD163 antigen-like 1, CD163b) (Biotin)
Ask
View Details 
MBS6282819-02 5x 0.2 mL
CD163L1, CT (CD163L1, CD163B, M160, Scavenger receptor cysteine-rich type 1 protein M160, CD163 antigen-like 1, CD163b) (Biotin)
Ask
View Details