Gentisein
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2].
Product Specifications
CAS Number
529-49-7
Product Name Alternative
NSC 329491; 1,3,7-Trihydroxyxanthone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gentisein.html
Purity
98.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=C(C=C2O)O)OC3=C1C=C(C=C3)O
Molecular Formula
C13H8O5
Molecular Weight
244.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45 (5) :793-798. |[2]Tzankova, Virginia et al. (2010) . Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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