Gentisein

Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2].

Product Specifications

CAS Number

[529-49-7]

Product Name Alternative

NSC 329491; 1,3,7-Trihydroxyxanthone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gentisein.html

Purity

98.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=C(C=C2O)O)OC3=C1C=C(C=C3)O

Molecular Formula

C13H8O5

Molecular Weight

244.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45 (5) :793-798. |[2]Tzankova, Virginia et al. (2010) . Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2.