Estragole-d4

Estragole-d4 is deuterated labeled Estragole (HY-N5060) . Estragole (4-Allylanisole) is a relatively nontoxic volatile terpenoid ether and major component of the essential oil from many plants. Estragole significantly triggers Apoptosis, suppresses LPS-induced intracellular ROS production. Estragole activats Nrf-2 and regulates NF-κB. Estragole has anti-toxoplasma, anti-inflammatory, anti-edema, antioxidant and immunomodulatory properties. Estragole blocks DRG neuron excitability. Estragole has improves gastric ulcer activity[1][2][3][4][5][6][7][8][9][10][11][12][13].

Product Specifications

CAS Number

[1335401-40-5]

Product Name Alternative

4-Allylanisole-d4

UNSPSC

12352005

Hazard Statement

H227, H302, H315, H317, H319, H341, H351, H402, H412

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.9

Solubility

10 mM in DMSO

Smiles

C=CCC1=C([2H])C([2H])=C(C([2H])=C1[2H])OC

Molecular Formula

C10H8D4O

Molecular Weight

152.23

Precautions

H227, H302, H315, H317, H319, H341, H351, H402, H412

References & Citations

[1]Leal-Cardoso JH, et al. Effects of estragole on the compound action potential of the rat sciatic nerve. Braz J Med Biol Res. 2004 Aug;37 (8) :1193-8.|[2]Oliveira CB, et al. Anti-Toxoplasma Activity of Estragole and Thymol in Murine Models of Congenital and Noncongenital Toxoplasmosis. J Parasitol. 2016 Jun;102 (3) :369-76.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.