G7-18NATE
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2].
Product Specifications
CAS Number
936728-13-1
UNSPSC
12352209
Target
EGFR
Type
Peptides
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g7-18nate.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@@H](CSC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC7=CC=CC=C67)NC5=O
Molecular Formula
C67H80N14O19S
Molecular Weight
1417.50
References & Citations
[1]Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24 (20) :3739. |[2]Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133 (2) :607-15.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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