Aldose reductase-IN-7
Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aldose-reductase-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)CN(C1=CC=C([N+]([O-])=O)C=C1C23OC(CC4=CC=C(OC)C=C4)=NN3)C2=O
Molecular Formula
C21H20N4O7
Molecular Weight
440.41
References & Citations
[1]Güleç Ö, et al. Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies. Bioorg Chem. 2024 Apr;145:107221.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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