Radafaxine
Radafaxine ((S, S) -Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT) . Radafaxine is an active metabolite of Bupropion[1][2].
Product Specifications
CAS Number
192374-14-4
Product Name Alternative
(S, S) -Hydroxybupropion; GW-353162A (free base) ; BW-306U (free base)
UNSPSC
12352005
Target
Drug Metabolite; Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/radafaxine.html
Solubility
10 mM in DMSO
Smiles
O[C@]1(C2=CC=CC(Cl)=C2)[C@H](C)NC(C)(C)CO1
Molecular Formula
C13H18ClNO2
Molecular Weight
255.74
References & Citations
[1]Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57 (6) :640-6.|[2]Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19 (3) :163-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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