Oleamide
Endogenous Sleep-inducing Lipid
Product Specifications
Background
Originally identified in the cerebrospinal fluid of sleep-deprived cats acting as an inducer of physiological sleep in animals (1). Displays agonist activity at cannabinoid CB1 receptors (Ki=8.13 µM) (2). Activates PPARΥ (3). Produces vasodilator effects in rats (4). Displays neuroprotective effects (5) and attenuates sepsis-induced intestinal injury (6).
CAS Number
301-02-0
Product Name Alternative
9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Neuroscience | Neurotransmission | Neurotransmitter Receptors
Purity
>99% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White to off-white powder
Solubility
May be dissolved in DMSO (25 mg/ml); or Ethanol (40 mg/ml)
Molecular Formula
C18H35NO
Molecular Weight
281.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. DL Boger et al. 1998 Curr. Pharm. Des. 4:303.
2. JD Leggett et al. 2004 Br. J. Pharmacol. 141:253.
3. M Dionisi et al. 2012 Lipids Health Dis. 11:51.
4. C Hernandez-Diaz et al. 2020 Cannabis Cannabinoid Res. 5:42.
5. M Maya-Lopez et al. 2020 Neurotox. Res. 37:126.
6. Z Zou et al. Mediators Inflamm. 2019 2019:7854389 (eCollection 2019).
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