Oleamide

Endogenous Sleep-inducing Lipid

Product Specifications

Background

Originally identified in the cerebrospinal fluid of sleep-deprived cats acting as an inducer of physiological sleep in animals (1). Displays agonist activity at cannabinoid CB1 receptors (Ki=8.13 µM) (2). Activates PPARΥ (3). Produces vasodilator effects in rats (4). Displays neuroprotective effects (5) and attenuates sepsis-induced intestinal injury (6).

Product Name Alternative

9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide

UNSPSC

41116105

Source

Synthetic

Purity

>99% (TLC); NMR (Conforms)

Weight

0.005

Format

White to off-white powder

Solubility

May be dissolved in DMSO (25 mg/ml); or Ethanol (40 mg/ml)

Molecular Formula

C18H35NO

Molecular Weight

281.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. DL Boger et al. 1998 Curr. Pharm. Des. 4:303. 2. JD Leggett et al. 2004 Br. J. Pharmacol. 141:253. 3. M Dionisi et al. 2012 Lipids Health Dis. 11:51. 4. C Hernandez-Diaz et al. 2020 Cannabis Cannabinoid Res. 5:42. 5. M Maya-Lopez et al. 2020 Neurotox. Res. 37:126. 6. Z Zou et al. Mediators Inflamm. 2019 2019:7854389 (eCollection 2019).