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Withanone (Standard)

Withanone (Standard) is the analytical standard of Withanone. This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases[1][2].

Product Specifications

CAS Number

27570-38-3

UNSPSC

12352005

Target

IGluR; Reference Standards

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/withanone-standard.html

Smiles

C[C@@]12[C@]3([H])[C@]([C@H](O4)[C@H]4[C@]1(CC=CC2=O)O)([H])[C@@]5([H])[C@@](C)([C@]([C@@H]([C@@](O6)([H])CC(C)=C(C)C6=O)C)(O)CC5)CC3

Molecular Formula

C28H38O6

Molecular Weight

470.60

References & Citations

[1]Pandey A, et al. Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction. Cytokine. 2018 Feb;102:211-221.|[2]Dar NJ, et al. Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol. 2017 Sep;54 (7) :5061-5073.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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