Fmoc-Ser (O-α-D-GalNAc (OAc) 3) -OH

Fmoc-Ser (O-α-D-GalNAc (OAc) 3) -OH is a agent for cancer. Fmoc-Ser (O-α-D-GalNAc (OAc) 3) -OH is a pharmaceutical intermediate. Fmoc-Ser (O-α-D-GalNAc (OAc) 3) -OH can be used for synthesizing glycopeptides and cancer vaccines. Fmoc-Ser (O-α-D-GalNAc (OAc) 3) -OH can bind to HEK293 cells stably expressing zebrafish NOP receptor (Ki = 3.81 nM) [1][2][3].

Product Specifications

CAS Number

[120173-57-1]

Product Name Alternative

Fmoc-Ser- (GalNAc (Ac) 3-alpha-D) -OH; Fmoc-Ser[GalNAc (Ac) 3-α-D]-OH; Fmoc-Ser (Ac3AcNH-α-Gal) -OH

UNSPSC

12352005

Hazard Statement

H302, H351

Target

Amino Acid Derivatives; Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Fmoc-Ser_O-_alpha_-D-GalNAc_OAc_3_-OH.html

Purity

99.12

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N[C@H](C(O)=O)CO[C@@H](O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O)[C@@H]1NC(C)=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Molecular Formula

C32H36N2O13

Molecular Weight

656.63

Precautions

H302, H351

References & Citations

[1]Eberling J, et al. Chemoselective Removal of Protecting Groups from O-Glycosyl Amino Acid and Peptide (Methoxyethoxy) ethyl Esters Using Lipases and Papain. J Org Chem. 1996 Apr 19;61 (8) :2638-2646.|[2]Arsequell G, et al. Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ. Org Biomol Chem. 2011 Sep 7;9 (17) :6133-42.|[3]Abdel-Aal AB, et al. Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based Toll-like receptor 2 ligand. J Med Chem. 2012 Aug 9;55 (15) :6968-74.