AKT-IN-25
Product Specifications
UNSPSC Description
AKT-IN-25 (Compound 14a) is an inhibitor for Akt, that inhibits the phosphorylation of Akt, and thereby inhibits the PI3K/Akt/mTOR signaling pathway. AKT-IN-25 arrests the cell cycle at G1 phase, inhibits the cell migration of PANC-1, and inhibits the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2 with IC50s of 3.05, 1.32, and 3.85 μM, respectively[1].
Target Antigen
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt-in-25.html
Smiles
O=C(N1C=C(N=N1)C2=CC=CC=C2)N3CCCCC3
Molecular Weight
256.30
References & Citations
[1]Pecoraro C, et al., Synthesis and biological evaluation of a new class of azole urea compounds as Akt inhibitors with promising anticancer activity in pancreatic cancer models. Bioorg Chem. 2024 Dec;153:107959.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169413/AKT-IN-25-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169413/
Clinical Information
No Development Reported
CAS Number
1619929-59-7
Curated Selection
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