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AKT-IN-25

AKT-IN-25 (Compound 14a) is an inhibitor for Akt, that inhibits the phosphorylation of Akt, and thereby inhibits the PI3K/Akt/mTOR signaling pathway. AKT-IN-25 arrests the cell cycle at G1 phase, inhibits the cell migration of PANC-1, and inhibits the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2 with IC50s of 3.05, 1.32, and 3.85 μM, respectively[1].

Product Specifications

CAS Number

[1619929-59-7]

UNSPSC

12352005

Target

Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akt-in-25.html

Smiles

O=C(N1C=C(N=N1)C2=CC=CC=C2)N3CCCCC3

Molecular Formula

C14H16N4O

Molecular Weight

256.30

References & Citations

[1]Pecoraro C, et al., Synthesis and biological evaluation of a new class of azole urea compounds as Akt inhibitors with promising anticancer activity in pancreatic cancer models. Bioorg Chem. 2024 Dec;153:107959.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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