VUF 10214

VUF 10214 is a H4 receptor ligand with a pKi of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases[1].

Product Specifications

CAS Number

[848837-33-2]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vuf-10214.html

Smiles

O=C1NC2=C(N=C1N3CCN(CC3)C)C=C(C(Cl)=C2)Cl

Molecular Formula

C13H14Cl2N4O

Molecular Weight

313.18

References & Citations

[1]Smits RA, et al. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51 (8) :2457-67.