BMS-779788

BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.

Product Specifications

CAS Number

[918348-67-1]

Product Name Alternative

EXEL04286652; XL-652; BMS-788

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/BMS-779788.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C)(C)C1=CN(C2=CC=C(C3=CC=CC(S(=O)(C)=O)=C3)C=C2)C(C(C)(C4=CC=CC=C4Cl)C)=N1

Molecular Formula

C28H29ClN2O3S

Molecular Weight

509.06

Precautions

H302, H315, H319

References & Citations

[1]Kirchgessner TG, et al. Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates. J Pharmacol Exp Ther. 2015 Feb;352 (2) :305-14.|[2]Kick E, et al. Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ. Bioorg Med Chem Lett. 2015 Jan 15;25 (2) :372-7.