Bio-AMS (TFA)
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1].
Product Specifications
Product Name Alternative
PK-8165
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bio-ams-tfa.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4.OC(C(F)(F)F)=O
Molecular Formula
C22H30F3N9O9S2
Molecular Weight
685.65
References & Citations
[1]Bockman MR, Aldrich CC, et al. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. ACS Infect Dis. 2018 Jul 13;4 (7) :1102-1113.|[2]Tiwari D, Schnappinger D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018 Apr 25;10 (438) :eaal1803.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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