Vinblastine (sulfate)

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

Product Specifications

CAS Number

[143-67-9]

Product Name Alternative

Vincaleukoblastine sulfate salt

UNSPSC

12352005

Hazard Statement

H302, H350, H360

Target

Autophagy; Microtubule/Tubulin; nAChR

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Vinblastine-sulfate.html

Purity

99.86

Solubility

DMSO : ≥ 44 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

[H][C@@]12C[C@@](C3=C(OC)C=C(N([C@]4([H])[C@@]56[C@]7([H])[C@](C=CCN7CC6)(CC)[C@@H](OC(C)=O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C(NC8=C9C=CC=C8)=C9CC[N@](C2)C[C@](O)(CC)C1.OS(=O)(O)=O

Molecular Formula

C46H60N4O13S

Molecular Weight

909.05

Precautions

H302, H350, H360

References & Citations

[1]McKay DB, et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203 (3) :372-6.|[2]Pandya P, et al. Molecular recognition pattern of cytotoxic alkaloid vinblastine with multiple targets. J Mol Graph Model. 2014 Nov;54:1-9.|[3]Calvi?o E, et al. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun;33 (4) :211-9.|[4]Selimovic D, et al. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug;18 (8) :980-97.|[5]Bánóczi Z, et al. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17;21 (11) :1948-55.