Pheanthine
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM) . Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM) [1].
Product Specifications
CAS Number
1263-79-2
UNSPSC
12352005
Target
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pheanthine.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC(C=C2C(CC3)=C4)=C4OC)C([C@@](N5C)([H])CC(C=C6OC(C=C7)=CC=C7C[C@@]2([H])N3C)=CC=C6OC)=C(CC5)C=C1OC
Molecular Formula
C38H42N2O6
Molecular Weight
622.75
References & Citations
[1]Cimanga Kanyanga R., et al., Isolation and structure elucidation of two antiprotozoal bisbenzylisoquinoline alkaloids from Triclisia gilletii stem bark. Phytochemistry Letters. 2018.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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