Pheanthine

Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM) . Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM) [1].

Product Specifications

CAS Number

1263-79-2

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pheanthine.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC(C=C2C(CC3)=C4)=C4OC)C([C@@](N5C)([H])CC(C=C6OC(C=C7)=CC=C7C[C@@]2([H])N3C)=CC=C6OC)=C(CC5)C=C1OC

Molecular Formula

C38H42N2O6

Molecular Weight

622.75

References & Citations

[1]Cimanga Kanyanga R., et al., Isolation and structure elucidation of two antiprotozoal bisbenzylisoquinoline alkaloids from Triclisia gilletii stem bark. Phytochemistry Letters. 2018.