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AChE-IN-74

AChE-IN-74 (Compound 10) is a modulator for cholinesterase. AChE-IN-74 inhibits the proliferation of liver cancer cell Hep3B and SkHep1 with IC50 of 3.6 and 19.9 μM. AChE-IN-74 exhibits a low embryonic toxicity in zebrafish models (10-15 μM) [1].

Product Specifications

UNSPSC

12352101

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-234.html

Smiles

O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)CN4CCN(CC5=CC=C(OC)C=C5)CC4

Molecular Formula

C26H26ClN3O2S

Molecular Weight

480.02

References & Citations

[1]Kisla M M, et al. Synthesis and Structure of Novel Phenothiazine Derivatives, and Compound Prioritization via In Silico Target Search and Screening for Cytotoxic and Cholinesterase Modulatory Activities in Liver Cancer Cells and In Vivo in Zebrafish[J]. ACS Omega, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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