PZ-1922 (free base)

PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively) . PZ-1922 free base reversibly inhibits MAO-B (pIC50: 8.93) . PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test[1].

Product Specifications

CAS Number

[1648745-65-6]

UNSPSC

12352005

Target

5-HT Receptor; Monoamine Oxidase

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pz-1922-free-base.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=CC(CN2C=CC3=C2C4=C(C=CC=C4)N=C3N5CCNCC5)=C1

Molecular Formula

C22H21ClN4

Molecular Weight

376.88

References & Citations

[1]Grychowska K, et al. Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J Med Chem. 2023 Nov 9;66 (21) :14928-14947.