1,3,5-Trihydroxy-4-prenylxanthone
1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) -induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2].
Product Specifications
CAS Number
53377-61-0
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE) ; NO Synthase; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-3-5-trihydroxy-4-prenylxanthone.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\CC1=C2C(C(C3=C(C(O)=CC=C3)O2)=O)=C(O)C=C1O
Molecular Formula
C18H16O5
Molecular Weight
312.32
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
INOS; PDE5
Frequently Asked Questions
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