Phenacetin

Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3].

Product Specifications

CAS Number

[62-44-2]

Product Name Alternative

Acetophenetidin

UNSPSC

12352005

Hazard Statement

H302, H350, H360

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/phenacetin.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=C(OCC)C=C1)=O

Molecular Formula

C10H13NO2

Molecular Weight

179.22

Precautions

H302, H350, H360

References & Citations

[2]Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct; 7 (10) : 1725–1731.|[3]Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014; 9 (2) : e89752.|[1]Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99 (21) :13926-31.